Coexistence of choline acetyltransferase and nerve growth factor receptors in the rat basal forebrain

D Dawbarn; S J Allen; F M Semenenko

doi:10.1016/0304-3940(88)90284-4

Coexistence of choline acetyltransferase and nerve growth factor receptors in the rat basal forebrain

Neurosci Lett. 1988 Nov 22;94(1-2):138-44. doi: 10.1016/0304-3940(88)90284-4.

Authors

D Dawbarn¹, S J Allen, F M Semenenko

Affiliation

¹ Department of Medicine (Care of the Elderly), University of Bristol, Bristol Royal Infirmary, U.K.

PMID: 2853851
DOI: 10.1016/0304-3940(88)90284-4

Abstract

Choline acetyltransferase (ChAT) and nerve growth factor (NGF) receptors have previously been shown to be expressed in magnocellular forebrain neurones in the rat. We have now examined their colocalization in these neurones. Using monoclonal antibodies raised against ChAT and NGF receptors we demonstrate here a high degree of colocalization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / enzymology
Brain / metabolism*
Choline O-Acetyltransferase / analysis*
Immunoenzyme Techniques
Nerve Growth Factors / metabolism
Neurons / metabolism
Rats
Rats, Inbred Strains
Receptors, Cell Surface / analysis*
Receptors, Nerve Growth Factor

Substances

Nerve Growth Factors
Receptors, Cell Surface
Receptors, Nerve Growth Factor
Choline O-Acetyltransferase