A Nonmetal-Containing Nitric Oxide Donor Activated with Single-Photon Green Light

Marco Blangetti; Aurore Fraix; Loretta Lazzarato; Elisabetta Marini; Barbara Rolando; Federica Sodano; Roberta Fruttero; Alberto Gasco; Salvatore Sortino

doi:10.1002/chem.201701889

A Nonmetal-Containing Nitric Oxide Donor Activated with Single-Photon Green Light

Chemistry. 2017 Jul 6;23(38):9026-9029. doi: 10.1002/chem.201701889. Epub 2017 Jun 9.

Authors

Marco Blangetti¹, Aurore Fraix², Loretta Lazzarato¹, Elisabetta Marini¹, Barbara Rolando¹, Federica Sodano¹, Roberta Fruttero¹, Alberto Gasco¹, Salvatore Sortino²

Affiliations

¹ Department of Science and Drug Technology, University of Torino, 10125, Torino, Italy.
² Laboratory of Photochemistry, Department of Drug Sciences, University of Catania, 95125, Catania, Italy.

PMID: 28543638
DOI: 10.1002/chem.201701889

Abstract

Using a facile synthetic route, an organic NO release agent based on a BODIPY light-harvesting antenna was devised. This compound is stable in the dark and delivers NO under photoexcitation with biologically favorable green light. Temporally regulated vasodilation capability is demonstrated on rat aorta by green-light-induced NO release.

Keywords: BODIPY; controlled release; nitric oxide; photoactivation; vasodilatation.

MeSH terms

Boron Compounds / chemistry
Chromatography, High Pressure Liquid / methods
Drug Liberation
Humans
Light
Nitric Oxide / chemistry*
Nitric Oxide Donors / chemistry*
Photons
Spectrometry, Fluorescence / methods
Spectrometry, Mass, Electrospray Ionization / methods
Vasodilation / drug effects

Substances

4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
Boron Compounds
Nitric Oxide Donors
Nitric Oxide