Pigmented trichoblastoma developed in a sebaceous nevus: HRAS mutation as a common molecular driver

Deborah Saraggi; Roberto Salmaso; Elisa Valentini; Giada Munari; Vincenzo Vindigni; Massimo Rugge; Matteo Fassan; Lorenzo Cerroni

doi:10.1016/j.prp.2017.03.012

Pigmented trichoblastoma developed in a sebaceous nevus: HRAS mutation as a common molecular driver

Pathol Res Pract. 2017 Jul;213(7):860-862. doi: 10.1016/j.prp.2017.03.012. Epub 2017 Mar 30.

Authors

Deborah Saraggi¹, Roberto Salmaso², Elisa Valentini², Giada Munari², Vincenzo Vindigni³, Massimo Rugge², Matteo Fassan⁴, Lorenzo Cerroni⁵

Affiliations

¹ Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy; Clinic of Plastic and Reconstructive Surgery, University of Padua, Padua, Italy.
² Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy.
³ Clinic of Plastic and Reconstructive Surgery, University of Padua, Padua, Italy.
⁴ Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy. Electronic address: [email protected].
⁵ Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria.

PMID: 28554764
DOI: 10.1016/j.prp.2017.03.012

Abstract

A 40-year-old woman presented with a pigmented nodule on a previously existing yellowish, verrucous plaque on the scalp. The histological diagnosis was consistent with a pigmented trichoblastoma developed within a sebaceous nevus (SN). A multigene hotspot mutational profiling of the BRAF, NRAS, HRAS and KRAS genes was carried out, and a shared G13R HRAS mutation in both the trichoblastoma and the sebaceous nevus components was found. These data support a common molecular landscape of the two lesions.

Keywords: HRAS; Pigmented trichoblastoma; Sebaceous nevus.

Publication types

Case Reports

MeSH terms

Adult
Biomarkers, Tumor / analysis
Biomarkers, Tumor / genetics*
DNA Mutational Analysis
Female
GTP Phosphohydrolases / genetics
Genetic Predisposition to Disease
Head and Neck Neoplasms / chemistry
Head and Neck Neoplasms / genetics*
Head and Neck Neoplasms / pathology
Head and Neck Neoplasms / surgery
Humans
Immunohistochemistry
Membrane Proteins / genetics
Mutation*
Nevus, Sebaceous of Jadassohn / genetics*
Nevus, Sebaceous of Jadassohn / pathology
Nevus, Sebaceous of Jadassohn / surgery
Phenotype
Proto-Oncogene Proteins B-raf / genetics
Proto-Oncogene Proteins p21(ras) / genetics*
Scalp / chemistry
Scalp / pathology*
Scalp / surgery
Sebaceous Gland Neoplasms / chemistry
Sebaceous Gland Neoplasms / genetics*
Sebaceous Gland Neoplasms / pathology
Sebaceous Gland Neoplasms / surgery

Substances

Biomarkers, Tumor
KRAS protein, human
Membrane Proteins
BRAF protein, human
Proto-Oncogene Proteins B-raf
GTP Phosphohydrolases
NRAS protein, human
HRAS protein, human
Proto-Oncogene Proteins p21(ras)