Gli-fully Halting the Progression of Fibrosis

Christian F Guerrero-Juarez; Maksim V Plikus

doi:10.1016/j.stem.2017.05.003

Gli-fully Halting the Progression of Fibrosis

Cell Stem Cell. 2017 Jun 1;20(6):735-736. doi: 10.1016/j.stem.2017.05.003.

Authors

Christian F Guerrero-Juarez¹, Maksim V Plikus²

Affiliations

¹ Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
² Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: [email protected].

PMID: 28575684
DOI: 10.1016/j.stem.2017.05.003

Abstract

Activating triggers, selective markers, and the residual regenerative potential of scar-forming myofibroblasts are largely determined by their origin. In this issue of Cell Stem Cell, Schneider et al. report that bone marrow myofibroblasts derive from Gli1⁺ mesenchymal stromal cells and that a Gli inhibitor targets them for elimination in mice and humans, ameliorating fibrosis.

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MeSH terms

Animals
Fibrosis
Humans
Mesenchymal Stem Cells*
Mice
Myofibroblasts
Primary Myelofibrosis*
Zinc Finger Protein GLI1

Substances

GLI1 protein, human
Zinc Finger Protein GLI1