Mitotic Bookmarking: Maintaining the Stem Cell Identity during Mitosis

Xin Huang; Jianlong Wang

doi:10.1016/j.stem.2017.05.002

Mitotic Bookmarking: Maintaining the Stem Cell Identity during Mitosis

Cell Stem Cell. 2017 Jun 1;20(6):741-742. doi: 10.1016/j.stem.2017.05.002.

Authors

Xin Huang¹, Jianlong Wang²

Affiliations

¹ The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
² The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: [email protected].

PMID: 28575687
DOI: 10.1016/j.stem.2017.05.002

Abstract

In Cell Reports, Liu et al. (2017) investigate mechanisms for how pluripotent stem cells maintain their identity during cell division. They show that the histone mark H3K27ac and pluripotency transcription factors remain associated with mitotic chromatin in ESCs and during iPSC reprogramming, demonstrating the importance of mitotic bookmarking in pluripotency.

Publication types

Comment

MeSH terms

Chromatin
Histone Code*
Mitosis
Pluripotent Stem Cells*
Transcription Factors

Substances

Chromatin
Transcription Factors