The Troublesome Epidemiology of Barrett's Esophagus and Esophageal Adenocarcinoma

Jennifer L Schneider; Douglas A Corley

doi:10.1016/j.giec.2017.03.002

The Troublesome Epidemiology of Barrett's Esophagus and Esophageal Adenocarcinoma

Gastrointest Endosc Clin N Am. 2017 Jul;27(3):353-364. doi: 10.1016/j.giec.2017.03.002.

Authors

Jennifer L Schneider¹, Douglas A Corley²

Affiliations

¹ Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA. Electronic address: [email protected].
² Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA; San Francisco Medical Center, Kaiser Permanente Northern California, San Francisco, CA 94115, USA.

PMID: 28577761
DOI: 10.1016/j.giec.2017.03.002

Abstract

Barrett's esophagus and esophageal adenocarcinoma diagnoses have increased markedly in recent decades. Recent research with patients diagnosed with Barrett's esophagus (the only known precursor for esophageal adenocarcinoma) and esophageal adenocarcinoma has identified several modifiable and nonmodifiable potential risk factors. Consistent risk factors for both disorders include increasing age, male sex, white non-Hispanic race/ethnicity, gastroesophageal reflux disease, lack of infection with Helicobacter pylori, smoking, abdominal obesity, and a Western diet. The authors present detailed discussions of these risk factors along with possible explanations for some apparent discrepancies and ideas for future study.

Keywords: Barrett’s esophagus; Epidemiology; Esophageal adenocarcinoma.

Publication types

Review

MeSH terms

Adenocarcinoma / epidemiology*
Adenocarcinoma / etiology
Barrett Esophagus / epidemiology*
Barrett Esophagus / etiology
Esophageal Neoplasms / epidemiology*
Esophageal Neoplasms / etiology
Female
Gastroesophageal Reflux
Helicobacter Infections
Helicobacter pylori
Humans
Male
Risk Factors