Association Studies of Bone Morphogenetic Protein 2 Gene Polymorphisms With Acute Rejection in Kidney Transplantation Recipients

M-S Park; S K Kim; H J Park; H Seok; S W Kang; S H Lee; Y G Kim; J Y Moon; T H Kim; Y H Kim; S W Kang; J-H Chung; K H Jeong

doi:10.1016/j.transproceed.2017.03.019

Association Studies of Bone Morphogenetic Protein 2 Gene Polymorphisms With Acute Rejection in Kidney Transplantation Recipients

Transplant Proc. 2017 Jun;49(5):1012-1017. doi: 10.1016/j.transproceed.2017.03.019.

Authors

M-S Park¹, S K Kim², H J Park², H Seok², S W Kang², S H Lee³, Y G Kim³, J Y Moon³, T H Kim⁴, Y H Kim⁴, S W Kang⁴, J-H Chung⁵, K H Jeong³

Affiliations

¹ Department of Surgery, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
² Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
³ Department of Nephrology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
⁴ Department of Nephrology, School of Medicine, In Je University, Busan, Republic of Korea.
⁵ Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. Electronic address: [email protected].

PMID: 28583517
DOI: 10.1016/j.transproceed.2017.03.019

Abstract

Objective: Bone morphogenetic proteins (BMP) belong to the transforming growth factor beta superfamily of proteins. This study was performed to evaluate the association of BMP gene polymorphisms with acute renal allograft rejection (AR) and graft dysfunction (GD) in Koreans.

Methods: Three hundred thirty-one patients who had kidney transplantation procedures were recruited. Transplantation outcomes were determined in terms of AR and GD criteria. We selected six single nucleotide polymorphisms (SNPs): rs1979855 (5' near gene), rs1049007 (Ser87Ser), rs235767 (intron), rs1005464 (intron), rs235768 (Arg190Ser), and rs3178250 (3; untranslated region).

Results: Among the six SNPs tested, the rs235767, rs1005464, and rs3178250 SNPs were significantly associated with AR (P < .05). The rs1049007 and rs235768 SNPs also showed an association with GD (P < .05).

Conclusions: In conclusion, these results suggest that the BMP2 gene polymorphism may be related to the development of AR and GD in kidney transplant recipients.

MeSH terms

Adult
Bone Morphogenetic Protein 2 / genetics*
Female
Genetic Predisposition to Disease / genetics*
Genotype
Graft Rejection / genetics*
Humans
Kidney Transplantation*
Male
Middle Aged
Polymorphism, Single Nucleotide

Substances

Bone Morphogenetic Protein 2