Abstract
We investigated the inhibitory effects of several plant extracts on advanced glycation end-products (AGEs) formation. Among tested samples, the flower extract of Magnolia coco showed significant inhibition of AGE formation. We isolated and characterized procyanidin oligomer and four other compounds from the flowers, and evaluated their inhibitory effects on AGE formation and the AGE-derived crosslink-cleaving activity of the isolated compounds.
Keywords:
AGE-derived crosslink-cleaving activity; Magnolia coco; advanced glycation end products (AGEs); procyanidin oligomer.
MeSH terms
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Biflavonoids / chemistry*
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Biflavonoids / isolation & purification
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Catechin / chemistry*
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Catechin / isolation & purification
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Flowers / chemistry*
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Fructose / chemistry
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Glucose / chemistry
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Glycation End Products, Advanced / antagonists & inhibitors*
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Glycosylation
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Humans
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Magnolia / chemistry*
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Plant Extracts / chemistry
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Polyphenols / chemistry*
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Polyphenols / isolation & purification
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Proanthocyanidins / chemistry*
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Proanthocyanidins / isolation & purification
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Serum Albumin / chemistry
Substances
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Biflavonoids
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Glycation End Products, Advanced
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Plant Extracts
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Polyphenols
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Proanthocyanidins
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Serum Albumin
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Fructose
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procyanidin
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Catechin
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Glucose