Topographic outcomes after corneal collagen crosslinking in progressive keratoconus: 1-year follow-up

Arq Bras Oftalmol. 2017 Mar-Apr;80(2):93-96. doi: 10.5935/0004-2749.20170023.

Abstract

Purpose:: We aimed to report and analyze topographic and refractive outcomes following corneal collagen crosslinking (CXL) in patients with progressive keratoconus (KC).

Methods:: We performed a retrospective, analytical, and observational study of 100 eyes from 74 progressive KC patients who underwent CXL at the Eye Hospital of Paraná. Keratometric values were analyzed preoperatively as well as 3 and 12 months postoperatively.

Results:: For a total of 100 eyes, 68 belonged to male patients. The mean age of our study population was 19.9 ± 5.61 years. The average visual acuity and topographic parameters overall were stable after 1 year (p<0.05). After 3 months, steepest keratometry reading (K2) and maximum keratometry (Kmax) were significantly decreased (p<0.05). Regarding topographic astigmatism (dK), there was no significant difference between the 3-month and 12-month follow-ups. When we made comparisons between genders following CXL, there were no significant differences related to the changes in Kmax, K2, and spectacle-corrected distance visual acuity (SCDVA).

Conclusions:: CXL promoted stabilization or improvement of keratometric values and visual acuity. We found that keratoconus apex stability may be achieved 3 months after the procedure. There was no significant difference in keratometric and refractive values measured between male and female patients.

Publication types

  • Observational Study

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Collagen / therapeutic use*
  • Corneal Topography / statistics & numerical data*
  • Cross-Linking Reagents / therapeutic use*
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Keratoconus / physiopathology
  • Keratoconus / therapy*
  • Male
  • Preoperative Care
  • Refraction, Ocular / physiology
  • Retrospective Studies
  • Sex Factors
  • Treatment Outcome
  • Ultraviolet Therapy / methods
  • Visual Acuity / physiology
  • Young Adult

Substances

  • Cross-Linking Reagents
  • Collagen