Low dose versus high dose anti-snake venom therapy in the treatment of haematotoxic snake bite in South India

Trop Doct. 2017 Oct;47(4):300-304. doi: 10.1177/0049475517712804. Epub 2017 Jun 7.

Abstract

Most of the studies on the appropriate dose of anti-snake venom (ASV) are from tertiary hospitals and the guidelines are unclear. Our observational study compared the outcomes of two prevalent treatment regimes for haematotoxic snake bite in a secondary care hospital in South India. The time to normalisation of whole blood clotting time, mortality and complications were not different between the groups. The average dose of ASV required in the low and high dose groups were 106 mL and 246 mL, respectively. Consequently, patients who received low dose ASV incurred approximately 50% less expense. Urticarial rashes were also significantly fewer in the low dose group.

Keywords: Haematotoxic snake bite; anti-snake venom dose.

MeSH terms

  • Adult
  • Antivenins / administration & dosage*
  • Blood Coagulation Disorders / therapy*
  • Female
  • Humans
  • Immunologic Factors / administration & dosage*
  • India
  • Male
  • Middle Aged
  • Snake Bites / therapy*
  • Snake Venoms / immunology
  • Tertiary Care Centers
  • Young Adult

Substances

  • Antivenins
  • Immunologic Factors
  • Snake Venoms