Direct catalytic enantioselective Mannich-type reaction of α,α-dithioacetonitriles with imines using chiral bis(imidazoline)-Pd complexes

Masaru Kondo; Hikari Saito; Shuichi Nakamura

doi:10.1039/c7cc03307a

Direct catalytic enantioselective Mannich-type reaction of α,α-dithioacetonitriles with imines using chiral bis(imidazoline)-Pd complexes

Chem Commun (Camb). 2017 Jun 20;53(50):6776-6779. doi: 10.1039/c7cc03307a.

Authors

Masaru Kondo¹, Hikari Saito, Shuichi Nakamura

Affiliation

¹ Department of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan. [email protected].

PMID: 28597896
DOI: 10.1039/c7cc03307a

Abstract

The first highly enantioselective reaction of α,α-dithioacetonitriles with imines has been developed. Good yields and enantioselectivity were observed for the reaction of various imines using chiral bis(imidazoline) catalysts. The obtained products can be converted into β-aminonitrile or 1,3-diaminoketone.