Pharmacogenetics-based optimisation of atazanavir treatment: potential role of new genetic predictors

Drug Metab Pers Ther. 2017 May 24;32(2):115-117. doi: 10.1515/dmpt-2017-0006.
No abstract available

Keywords: CYP3A; PPARA; UGT1A1; atazanavir; hyperbilirubinemia.

Publication types

  • Letter
  • Observational Study

MeSH terms

  • Adult
  • Atazanavir Sulfate / adverse effects*
  • Atazanavir Sulfate / pharmacokinetics*
  • Atazanavir Sulfate / therapeutic use
  • Cytochrome P-450 CYP3A / genetics*
  • Female
  • Glucuronosyltransferase / genetics*
  • HIV Protease Inhibitors / adverse effects
  • HIV Protease Inhibitors / pharmacokinetics
  • HIV Protease Inhibitors / therapeutic use
  • Humans
  • Male
  • Middle Aged
  • PPAR alpha / genetics*
  • Pharmacogenomic Variants / genetics
  • Polymorphism, Single Nucleotide / genetics

Substances

  • HIV Protease Inhibitors
  • PPAR alpha
  • Atazanavir Sulfate
  • CYP3A5 protein, human
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • UGT1A1 enzyme
  • Glucuronosyltransferase