Heavy Metal to Rock the Immune Infiltrate

Trends Immunol. 2017 Aug;38(8):539-541. doi: 10.1016/j.it.2017.05.007. Epub 2017 Jun 9.

Abstract

Two resource articles recently published in Cell demonstrate that the elevated phenotypic complexity of the immune infiltrate in human lung adenocarcinomas and renal cell carcinomas can be reliably dissected with mass cytometry. These findings may pave the way to a new era of precision cancer immunotherapy.

Keywords: CD4(+)CD25(+)FOXP3(+) regulatory T cells; CD8(+) cytotoxic T lymphocytes; dendritic cells; immune checkpoint blockers; natural killer cells; tumor-associated macrophages.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Flow Cytometry*
  • Humans
  • Immunotherapy
  • Mass Spectrometry*
  • Metals, Heavy*
  • Precision Medicine
  • Single-Cell Analysis / instrumentation*
  • Single-Cell Analysis / methods*
  • Tumor Microenvironment / immunology*

Substances

  • Metals, Heavy