Abstract
The operational impact of deltamethrin resistance on the efficacy of indoor insecticide applications to control Aedes aegypti was evaluated in Merida, Mexico. A randomized controlled trial quantified the efficacy of indoor residual spraying (IRS) against adult Ae. aegypti in houses treated with either deltamethrin (to which local Ae. aegypti expressed a high degree of resistance) or bendiocarb (to which local Ae. aegypti were fully susceptible) as compared to untreated control houses. All adult Ae. aegypti infestation indices during 3 months post-spraying were significantly lower in houses treated with bendiocarb compared to untreated houses (odds ratio <0.75; incidence rate ratio < 0.65) whereas no statistically significant difference was detected between the untreated and the deltamethrin-treated houses. On average, bendiocarb spraying reduced Ae. aegypti abundance by 60% during a 3-month period. Results demonstrate that vector control efficacy can be significantly compromised when the insecticide resistance status of Ae. aegypti populations is not taken into consideration.
MeSH terms
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Aedes / drug effects*
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Animals
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Housing
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Insecticide Resistance*
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Insecticides / administration & dosage
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Insecticides / pharmacology*
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Mexico
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Mosquito Control
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Nitriles / administration & dosage
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Nitriles / pharmacology*
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Phenylcarbamates / administration & dosage
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Phenylcarbamates / pharmacology
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Pyrethrins / administration & dosage
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Pyrethrins / pharmacology*
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Time Factors
Substances
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Insecticides
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Nitriles
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Phenylcarbamates
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Pyrethrins
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decamethrin
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bendiocarb
Grants and funding
This project received support from Emory Global Health Institute and Marcus Foundation (project #00052002), the Centers for Disease Control and Prevention (CDC: OADS BAA 2016-N-17844) and Mexico’s CONACYT (Project # 000000000255141). SAR is funded by National Health and Medical Research Council Senior Research Fellowship 1044698. The findings and conclusions in this paper are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.