Positron emission tomography: human brain function and biochemistry

Science. 1985 May 17;228(4701):799-809. doi: 10.1126/science.2860723.

Abstract

Positron emission tomography (PET) is an analytical imaging technique that provides a way of making in vivo measurements of the anatomical distribution and rates of specific biochemical reactions. This ability of PET to measure and image dynamic biochemistry builds a bridge between the basic and clinical neurosciences founded on the commonality of the types of measurements made. Clinical findings with PET in humans are suggesting hypotheses that can be tested rigorously in the basic science laboratory.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acoustic Stimulation
  • Bipolar Disorder / metabolism
  • Brain / diagnostic imaging*
  • Brain / metabolism
  • Brain Diseases / diagnostic imaging*
  • Brain Diseases / metabolism
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / metabolism
  • Cerebrovascular Circulation
  • Cerebrovascular Disorders / diagnostic imaging
  • Cerebrovascular Disorders / metabolism
  • Deoxyglucose / analogs & derivatives
  • Deoxyglucose / metabolism
  • Fluorodeoxyglucose F18
  • Glucose / metabolism
  • Humans
  • Huntington Disease / diagnostic imaging
  • Huntington Disease / metabolism
  • Kinetics
  • Mental Disorders / metabolism
  • Neurotransmitter Agents / metabolism
  • Oxygen Consumption
  • Pharmaceutical Preparations / metabolism
  • Pharmacology
  • Photic Stimulation
  • Tomography, Emission-Computed*
  • Visual Cortex / diagnostic imaging
  • Visual Cortex / physiology

Substances

  • Neurotransmitter Agents
  • Pharmaceutical Preparations
  • Fluorodeoxyglucose F18
  • Deoxyglucose
  • Glucose