Bottom-up synthesis of WS2 nanosheets with synchronous surface modification for imaging guided tumor regression

Shige Wang; Jiulong Zhao; Hailun Yang; Chenyao Wu; Fei Hu; Haizhou Chang; Guixiang Li; Dan Ma; Duowu Zou; Mingxian Huang

doi:10.1016/j.actbio.2017.06.014

Bottom-up synthesis of WS₂ nanosheets with synchronous surface modification for imaging guided tumor regression

Acta Biomater. 2017 Aug:58:442-454. doi: 10.1016/j.actbio.2017.06.014. Epub 2017 Jun 10.

Authors

Shige Wang¹, Jiulong Zhao², Hailun Yang¹, Chenyao Wu¹, Fei Hu¹, Haizhou Chang¹, Guixiang Li², Dan Ma², Duowu Zou³, Mingxian Huang⁴

Affiliations

¹ College of Science, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai 200093, China.
² Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
³ Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China. Electronic address: [email protected].
⁴ College of Science, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai 200093, China. Electronic address: [email protected].

PMID: 28611005
DOI: 10.1016/j.actbio.2017.06.014

Abstract

Two-dimensional transition metal dichalcogenides (TMDs) have been receiving great attention as NIR photothermal transducing agent in tumor photothermal therapy. Keeping in mind the low efficiency of the conventional top-down exfoliated 2D TMDs and the complexity of their surface modifications, we herein proposed a bottom-up strategy for the one-pot hydrothermal and controlled synthesis of surface polyvinyl pyrrolidone (PVP) modified WS₂ nanosheets. The material design was based on the chelating-coordinating effect between the lone pair electrons of oxygen of PVP carbonyl group and the unoccupied orbital (5d orbitals) of tungsten. The WS₂ nanosheets with synchronous surface PVP grafting showed an excellent photothermal conversion performance, while the surface anchored PVP guaranteed its colloidal stability. Moreover, the strong X-ray attenuation ability and near-infrared (NIR) absorbance of WS₂-PVP_360kDa enabled the sensitive in vitro and in vivo computed tomography and photoacoustic imaging. The WS₂-PVP_360kDa nanosheets were biocompatible and exhibited promising in vitro and in vivo anti-cancer efficacy. Findings in this report may greatly promote the design of colloidal stable and biocompatible 2D TMDs and their future clinical translations.

Statement of significance: A bottom-up strategy for the one-pot and controlled synthesis of surface polyvinyl pyrrolidone (PVP) modified WS₂ nanosheets was proposed for the first time. By hydrothermally treating the mixture solution of tetrathiotungstate and PVP, Owing to the chelating-coordinating effect between the lone pair electrons of oxygen of PVP carbonyl group and the unoccupied orbital (5d orbitals) of tungsten, PVP was synchronously graphed on WS₂-PVP nanosheets surface. The formed WS₂-PVP nanosheets were colloidal stable, biocompatible, and exhibited promising computed tomography, photoacoustic imaging and tumor photothermal therapy efficacy both in vitro and in vivo.

Keywords: Bottom-up; Imaging; Photothermal regression; Tumor; Tungsten disulfide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Humans
Mice
Nanostructures* / chemistry
Nanostructures* / therapeutic use
Neoplasms, Experimental* / diagnostic imaging
Neoplasms, Experimental* / drug therapy
Povidone / chemistry
Povidone / pharmacology
Sulfides* / chemical synthesis
Sulfides* / chemistry
Sulfides* / pharmacology
Tomography, X-Ray Computed*
Tungsten Compounds* / chemical synthesis
Tungsten Compounds* / chemistry
Tungsten Compounds* / pharmacology
Xenograft Model Antitumor Assays

Substances

Sulfides
Tungsten Compounds
Povidone