Calcitonin gene-related peptide: potent vasodilator and major product of calcitonin gene

Lancet. 1985 Jul 6;2(8445):14-6. doi: 10.1016/s0140-6736(85)90059-5.

Abstract

In addition to calcitonin and katacalcin, the human calcitonin gene encodes a novel peptide--calcitonin gene-related peptide (CGRP)--a potent vasodilator. A sensitive and specific radioimmunoassay was developed to study plasma levels of CGRP in normal subjects. CGRP circulates at five times the concentration of calcitonin, suggesting that it may be an important physiological regulator of vascular tone and blood flow.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Animals
  • Calcitonin / blood
  • Calcitonin Gene-Related Peptide
  • Chromatography, High Pressure Liquid
  • Female
  • Humans
  • Immunoassay
  • Male
  • Middle Aged
  • Nerve Tissue Proteins / blood*
  • Nerve Tissue Proteins / physiology
  • Rats
  • Vasodilation*

Substances

  • Nerve Tissue Proteins
  • Calcitonin
  • Calcitonin Gene-Related Peptide