Dissecting the human microbiome with single-cell genomics

Andrew C Tolonen; Ramnik J Xavier

doi:10.1186/s13073-017-0448-7

Dissecting the human microbiome with single-cell genomics

Genome Med. 2017 Jun 14;9(1):56. doi: 10.1186/s13073-017-0448-7.

Authors

Andrew C Tolonen¹, Ramnik J Xavier^{2

3

4

5}

Affiliations

¹ Broad Institute of MIT and Harvard University, Cambridge, MA, 02142, USA. [email protected].
² Broad Institute of MIT and Harvard University, Cambridge, MA, 02142, USA. [email protected].
³ Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. [email protected].
⁴ Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. [email protected].
⁵ Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, 02139, USA. [email protected].

Abstract

Recent advances in genome sequencing of single microbial cells enable the assignment of functional roles to members of the human microbiome that cannot currently be cultured. This approach can reveal the genomic basis of phenotypic variation between closely related strains and can be applied to the targeted study of immunogenic bacteria in disease.

Publication types

Editorial
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Bacteria / genetics*
Genome, Bacterial*
Genomics / methods*
Humans
Microbiota*
Sequence Analysis, DNA / methods*

Abstract

Publication types

MeSH terms

Grants and funding