A master promoter of cell growth, mammalian target of rapamycin (mTOR) is upregulated in a large percentage of cancer cells. Still, targeting mTOR using rapamycin has a limited outcome in patients. Our recent results highlight the additional role of mTOR as a tumor suppressor, explaining these modest results in the clinic.
Keywords: autophagy; cancer metabolism; glutamoptosis; mTORC1; rapamycin; α-ketoglutarate.