Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

Xin Wei; Afsar Khan; Da Song; Zhi Dai; Ya-Ping Liu; Hao-Fei Yu; Bei Wang; Pei-Feng Zhu; Cai-Feng Ding; Xu-Dong Zhao; Yi-Fen Wang; Xiao-Dong Luo

doi:10.1007/s13659-017-0137-7

Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

Nat Prod Bioprospect. 2017 Aug;7(4):323-327. doi: 10.1007/s13659-017-0137-7. Epub 2017 Jun 15.

Authors

Xin Wei^{1

2

3}, Afsar Khan^{1

4}, Da Song⁵, Zhi Dai^{6

2}, Ya-Ping Liu^{1

3}, Hao-Fei Yu^{1

2

3}, Bei Wang^{1

2

3}, Pei-Feng Zhu^{1

2

3}, Cai-Feng Ding^{1

2

3}, Xu-Dong Zhao⁶, Yi-Fen Wang^{7

8}, Xiao-Dong Luo^{9

10}

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
² University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
³ Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, People's Republic of China.
⁴ Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, 22060, Pakistan.
⁵ Yunnan College of Business Management, Kunming, 650106, People's Republic of China.
⁶ Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, People's Republic of China.
⁷ State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China. [email protected].
⁸ Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, People's Republic of China. [email protected].
⁹ State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China. [email protected].
¹⁰ Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, People's Republic of China. [email protected].

Abstract

Three new pyridine type alkaloids, (-)-vinmajpyridines A-C (1-3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data. The new alkaloids were evaluated for their cytotoxicity against glioma initiating cell lines (GITC-3^# and GITC-18^#), glioblastoma cell lines (U-87MG and T98G), and lung cancer cell line A-549, but none of them was active at 20 μg/mL concentration.

Keywords: Apocynaceae; Cytotoxicity; Pyridine alkaloids; Vinca major.