ER Stress Promotes Inflammation through Re-wIREd Macrophages in Obesity

Benjamin P Garfinkel; Gökhan S Hotamisligil

doi:10.1016/j.molcel.2017.05.037

ER Stress Promotes Inflammation through Re-wIREd Macrophages in Obesity

Mol Cell. 2017 Jun 15;66(6):731-733. doi: 10.1016/j.molcel.2017.05.037.

Authors

Benjamin P Garfinkel¹, Gökhan S Hotamisligil²

Affiliations

¹ Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
² Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: [email protected].

PMID: 28622517
DOI: 10.1016/j.molcel.2017.05.037

Abstract

A new mechanism linking ER dysfunction to metabolic inflammation is discovered in a recent study by Shan et al. (2017), which demonstrated ER stress-induced rewiring of adipose tissue macrophage polarization by IRE1α activation, leading to impaired systemic glucose homeostasis.

MeSH terms

Adipose Tissue
Homeostasis
Humans
Inflammation
Macrophages*
Obesity*