RETRACTED: Role of fractalkine/CX3CR1 signaling pathway in the recovery of neurological function after early ischemic stroke in a rat model

Life Sci. 2017 Sep 1:184:87-94. doi: 10.1016/j.lfs.2017.06.012. Epub 2017 Jun 15.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the authors and Editor-in-Chief. Concern was raised about the reliability of the Western blot results, as detailed here: https://pubpeer.com/publications/7BB8F6559AF31100A59484E5D97802; and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. In addition, a portion of Figure 5A, CA3 ‘Positive control’ group appears to contain image similarities with Figure 5A, CA1 ‘CX3CR1 inhibitor’ group. The journal requested that the corresponding author comment on these concerns and provide the raw data. However, the authors were not able to satisfactorily fulfill this request and therefore the Editor-in-Chief decided to retract the article.

Keywords: CX3CR1; Early ischemic stroke; Fractalkine; Neurological function; Signaling pathway.

Publication types

  • Retracted Publication

MeSH terms

  • Animals
  • Blotting, Western
  • Brain Ischemia / physiopathology*
  • CX3C Chemokine Receptor 1
  • Chemokine CX3CL1 / metabolism*
  • Disease Models, Animal
  • Infarction, Middle Cerebral Artery
  • Interleukin-1beta / metabolism
  • Male
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Chemokine / metabolism*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Signal Transduction
  • Stroke / physiopathology*
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • CX3C Chemokine Receptor 1
  • CX3CR1 protein, rat
  • Chemokine CX3CL1
  • Cx3cl1 protein, rat
  • Interleukin-1beta
  • RNA, Messenger
  • Receptors, Chemokine
  • Tumor Necrosis Factor-alpha