Trifluoromethyl- and Fluoroalkylselenolations of Alkynyl Copper(I) Compounds

Clément Ghiazza; Thierry Billard; Anis Tlili

doi:10.1002/chem.201702028

Trifluoromethyl- and Fluoroalkylselenolations of Alkynyl Copper(I) Compounds

Chemistry. 2017 Jul 26;23(42):10013-10016. doi: 10.1002/chem.201702028. Epub 2017 Jul 5.

Authors

Clément Ghiazza¹, Thierry Billard^{1

2}, Anis Tlili¹

Affiliations

¹ Institute of Chemistry and Biochemistry (ICBMS-UMR CNRS 5246), Univ Lyon, Université Lyon 1, CNRS, 43 Bd du 11 Novembre 1918, 69622, Villeurbanne, France.
² CERMEP-in vivo imaging, Groupement Hospitalier Est, 59 Bd Pinel, 69003, Lyon, France.

PMID: 28635038
DOI: 10.1002/chem.201702028

Abstract

The successful perfluoroalkylselenolation of alkynyl copper(I) compounds is described herein. The reaction occurs under oxidant free conditions at room temperature. This convenient one-pot procedure is based on the in situ generation of trifluoromethylselenyl chlorides. The developed system shows high functional group tolerance and also promotes the employment of fluoroalkyl derivatives.

Keywords: alkynes; copper; fluorine; selenium; trifluoromethylselenolation.