Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant

Lisheng Lin; Miho Takahashi-Igari; Yoshiaki Kato; Yoshihiro Nozaki; Mana Obata; Hiromi Hamada; Hitoshi Horigome

doi:10.1155/2017/6570465

Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant

Case Rep Pediatr. 2017:2017:6570465. doi: 10.1155/2017/6570465. Epub 2017 May 30.

Authors

Lisheng Lin^{1

2}, Miho Takahashi-Igari¹, Yoshiaki Kato¹, Yoshihiro Nozaki¹, Mana Obata³, Hiromi Hamada³, Hitoshi Horigome^{1

2}

Affiliations

¹ Department of Child Health, University of Tsukuba, Tsukuba, Japan.
² Department of Pediatric Cardiology, Ibaraki Children's Hospital, Mito, Japan.
³ Department of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, Japan.

Abstract

We report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricular arrhythmias were confirmed after birth. Genetic testing of the baby revealed a SCN5A R1193Q variant, which we considered could account for the various arrhythmias in this case.

Publication types

Case Reports