Structural components of nuclear integrity with gene regulatory potential

Kelli D Fenelon; Sevan Hopyan

doi:10.1016/j.ceb.2017.06.001

Structural components of nuclear integrity with gene regulatory potential

Curr Opin Cell Biol. 2017 Oct:48:63-71. doi: 10.1016/j.ceb.2017.06.001. Epub 2017 Jun 19.

Authors

Kelli D Fenelon¹, Sevan Hopyan²

Affiliations

¹ Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, M5S 1A8, Canada.
² Program in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, M5S 1A8, Canada; Division of Orthopaedic Surgery, Hospital for Sick Children and University of Toronto, M5G 1X8, Canada. Electronic address: [email protected].

PMID: 28641117
DOI: 10.1016/j.ceb.2017.06.001

Abstract

The nucleus is a mechanosensitive and load-bearing structure. Structural components of the nucleus interact to maintain nuclear integrity and have become subjects of exciting research that is relevant to cell and developmental biology. Here we outline the boundaries of what is known about key architectural elements within the nucleus and highlight their potential structural and transcriptional regulatory functions.

Publication types

Review

MeSH terms

Animals
Cell Nucleus / chemistry
Cell Nucleus / genetics
Cell Nucleus / metabolism*
Chromatin / metabolism
Extracellular Matrix / metabolism
Gene Expression Regulation
Humans
Mechanotransduction, Cellular
Nuclear Envelope / chemistry
Nuclear Envelope / metabolism
Nuclear Lamina / chemistry
Nuclear Lamina / metabolism

Substances

Chromatin

Grants and funding

MOP 126115/CIHR/Canada