SIRT4 Is a Regulator of Insulin Secretion

Elma Zaganjor; Sejal Vyas; Marcia C Haigis

doi:10.1016/j.chembiol.2017.06.002

SIRT4 Is a Regulator of Insulin Secretion

Cell Chem Biol. 2017 Jun 22;24(6):656-658. doi: 10.1016/j.chembiol.2017.06.002.

Authors

Elma Zaganjor¹, Sejal Vyas¹, Marcia C Haigis²

Affiliations

¹ Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
² Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: [email protected].

PMID: 28644956
DOI: 10.1016/j.chembiol.2017.06.002

Abstract

In a recent issue of Cell Metabolism, Anderson et al. (2017) report that SIRT4 regulates insulin sensitivity in the pancreas via activation of methylcrotonyl-CoA carboxylase 1 (MCCC1) by removal of dicarboxyacyl-lysine modifications. Thus, SIRT4 activates leucine catabolism and causes decreased secretion of insulin from the pancreas.

MeSH terms

Animals
Carbon-Carbon Ligases / metabolism
Insulin / metabolism*
Insulin Resistance
Insulin Secretion
Mice
Pancreas / metabolism
Sirtuins / metabolism*

Substances

Insulin
Sirtuins
Carbon-Carbon Ligases
methylcrotonoyl-CoA carboxylase