A preliminary study for the production of high specific activity radionuclides for nuclear medicine obtained with the isotope separation on line technique

Appl Radiat Isot. 2017 Sep:127:214-226. doi: 10.1016/j.apradiso.2017.06.022. Epub 2017 Jun 17.

Abstract

Radiopharmaceuticals represent a fundamental tool for nuclear medicine procedures, both for diagnostic and therapeutic purposes. The present work aims to explore the Isotope Separation On-Line (ISOL) technique for the production of carrier-free radionuclides for nuclear medicine at SPES, a nuclear physics facility under construction at INFN-LNL. Stable ion beams of strontium, yttrium and iodine were produced using the SPES test bench (Front-End) to simulate the production of 89Sr, 90Y, 125I and 131I and collected with good efficiency on suitable targets.

Keywords: ISOL; Radionuclides; Radiopharmaceuticals; SPES; Specific activity.

MeSH terms

  • Computer Simulation
  • Cyclotrons
  • Equipment Design
  • Feasibility Studies
  • Humans
  • Iodine Radioisotopes / isolation & purification
  • Nuclear Medicine / methods
  • Radiation Equipment and Supplies
  • Radioisotopes / isolation & purification*
  • Radionuclide Imaging
  • Radiopharmaceuticals / isolation & purification*
  • Strontium Radioisotopes / isolation & purification
  • Technology, Radiologic
  • Yttrium Radioisotopes / isolation & purification

Substances

  • Iodine Radioisotopes
  • Iodine-131
  • Radioisotopes
  • Radiopharmaceuticals
  • Strontium Radioisotopes
  • Yttrium Radioisotopes
  • Strontium-89
  • Yttrium-90
  • Iodine-125