Comparison of outcomes between muscle-sparing thoracotomy and video-assisted thoracic surgery in patients with cT1 N0 M0 lung cancer

J Thorac Cardiovasc Surg. 2017 Oct;154(4):1420-1429.e1. doi: 10.1016/j.jtcvs.2017.04.071. Epub 2017 May 20.

Abstract

Objective: To compare short-term complications and long-term survival outcomes between muscle-sparing thoracotomy (MST) and video-assisted thoracic surgery (VATS) groups using a propensity-score matching process.

Methods: One thousand eighty-three patients with cT1 N0 M0 lung cancer from January 2009 to December 2014 who underwent lobectomy and a systematic lymph node dissection were retrospectively included, and statistical analyses including a propensity-score matching process were used to compare short-term and long-term outcomes.

Results: Before propensity-score matching, for short-term surgical outcomes, the VATS group had fewer chest tube dwelling days (P < .001), less chest tube output (P < .001), shorter hospital stay, and fewer postoperative complications (P = .015). For long-term survival outcomes, the VATS group had a longer recurrence-free survival (P < .001) and overall survival (P < .001). After propensity-score matching, for short-term surgical outcomes, the VATS group had fewer chest tube dwelling days (P < .001), less chest tube output (P < .001), shorter hospital stay (P = .002), and fewer postoperative complications (P = .008). There was no difference in recurrence-free survival and overall survival between the 2 groups (P = .158 and P = .639, respectively).

Conclusions: VATS is less invasive and is associated with shorter length of hospital stay and fewer postoperative complications. The 2 surgical approaches have equivalent long-term survival outcomes.

Keywords: lung cancer; muscle-sparing thoracotomy; video-assisted thoracic surgery.

MeSH terms

  • Aged
  • China / epidemiology
  • Female
  • Humans
  • Length of Stay / statistics & numerical data
  • Lung Neoplasms* / mortality
  • Lung Neoplasms* / pathology
  • Lung Neoplasms* / surgery
  • Lymph Node Excision / methods
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Outcome and Process Assessment, Health Care
  • Pneumonectomy* / adverse effects
  • Pneumonectomy* / methods
  • Pneumonectomy* / statistics & numerical data
  • Postoperative Complications* / diagnosis
  • Postoperative Complications* / epidemiology
  • Propensity Score
  • Retrospective Studies
  • Thoracic Surgery, Video-Assisted* / adverse effects
  • Thoracic Surgery, Video-Assisted* / methods
  • Thoracic Surgery, Video-Assisted* / statistics & numerical data