Outbreak of CTX-M-15-Producing Enterotoxigenic Escherichia coli O159:H20 in the Republic of Korea in 2016

Jin Seok Kim; Jungsun Park; Eunkyung Shin; Soojin Kim; Sung Suck Oh; Hyo-Jin Yang; Dae-Won Kim; Kyung-Hwan Oh; Yonghoon Kim; Min Kim; Mun Ju Kwon; Kyoungin Na; Jin Lee; En-Hi Cho; Byung-Hak Kang; Hyo-Sun Kwak; Won Keun Seong; Junyoung Kim

doi:10.1128/AAC.00339-17

Outbreak of CTX-M-15-Producing Enterotoxigenic Escherichia coli O159:H20 in the Republic of Korea in 2016

Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00339-17. doi: 10.1128/AAC.00339-17. Print 2017 Sep.

Authors

Jin Seok Kim¹, Jungsun Park¹, Eunkyung Shin¹, Soojin Kim¹, Sung Suck Oh², Hyo-Jin Yang³, Dae-Won Kim³, Kyung-Hwan Oh¹, Yonghoon Kim¹, Min Kim², Mun Ju Kwon², Kyoungin Na⁴, Jin Lee⁴, En-Hi Cho⁴, Byung-Hak Kang¹, Hyo-Sun Kwak¹, Won Keun Seong¹, Junyoung Kim⁵

Affiliations

¹ Division of Enteric Diseases, Center for Infectious Diseases, National Institute of Health, Chungcheongbuk-do, Republic of Korea.
² Incheon Research Institute of Public Health and Environment, Incheon Metropolitan City, Republic of Korea.
³ Division of Biosafety Evaluation and Control, National Institute of Health, Chungcheongbuk-do, Republic of Korea.
⁴ Division of Infectious Disease Surveillance, Korea Centers for Disease Control and Prevention, Chungcheongbuk-do, Republic of Korea.
⁵ Division of Enteric Diseases, Center for Infectious Diseases, National Institute of Health, Chungcheongbuk-do, Republic of Korea [email protected].

Abstract

We investigated an outbreak of enterotoxigenic Escherichia coli (ETEC) O159:H20 associated with the consumption of a tossed-noodle dish in a high school in 2016. Thirty-three ETEC strains isolated from clinical and food samples were genetically indistinguishable. The outbreak strains were resistant to third-generation cephalosporins and harbored a bla_CTX-M-15 gene on a 97-kb self-transferable IncK plasmid. This is the first outbreak caused by CTX-M-15-producing ETEC strains.

Keywords: CTX-M-15; enterotoxigenic Escherichia coli O159:H20; outbreak.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cephalosporins / therapeutic use
Disease Outbreaks
Enterotoxigenic Escherichia coli / drug effects
Enterotoxigenic Escherichia coli / metabolism*
Escherichia coli Infections / epidemiology*
Humans
Plasmids / genetics
Republic of Korea / epidemiology
beta-Lactamases / metabolism*

Substances

Cephalosporins
beta-lactamase CTX-M-15
beta-Lactamases