Visible-Light-Mediated Addition of Phenacyl Bromides onto Cyclopropenes

Org Lett. 2017 Jul 7;19(13):3652-3655. doi: 10.1021/acs.orglett.7b01651. Epub 2017 Jun 28.

Abstract

Visible-light-promoted addition of α-bromoacetophenones onto the cyclopropene π-system in the presence of the fac-Ir(ppy)3 catalyst was shown to afford the corresponding 1(4H)-naphthalenones. The syn-carboarylation of the cyclopropene is followed by a cyclopropane ring opening under the basic conditions, allowing the formation of two C-C bonds and the generation of 1(4H)-naphthalenones bearing an all-carbon benzylic quaternary stereocenter.

Publication types

  • Research Support, Non-U.S. Gov't