Abstract
Host defense peptides are preferably administered as topical therapeutic agents. We have investigated whether peptide A3-APO can enter the circulation when applied to the ear skin. Efficacy of peptide monotherapy as transdermal administration option was assessed in a systemic mouse Acinetobacter baumannii model. A3-APO reduced mortality and demonstrated a statistically significant reduction of blood bacterial counts, regardless whether it was administered prior or after bacterial challenge. The peptidic metabolite of A3-APO was efficacious when applied to the ear or tail.
Keywords:
Bacterial counts; Multidrug resistance; Peptide antibiotic; Skin penetration; Survival.
MeSH terms
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Acinetobacter Infections / drug therapy*
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Acinetobacter Infections / microbiology
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Acinetobacter Infections / mortality
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Acinetobacter Infections / pathology
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / pathogenicity
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Acinetobacter baumannii / physiology
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Administration, Cutaneous
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Amino Acid Sequence
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Animals
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Anti-Bacterial Agents / pharmacology*
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Antimicrobial Cationic Peptides / pharmacology*
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Arginine / chemistry
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Bacteremia / drug therapy*
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Bacteremia / microbiology
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Bacteremia / mortality
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Bacteremia / pathology
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Bacterial Load / drug effects
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Carbapenems / pharmacology
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Colistin / pharmacology
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Disease Models, Animal
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Drug Resistance, Multiple, Bacterial / drug effects*
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Ear
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Humans
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Mice
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Proline / chemistry
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Skin / metabolism
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Survival Analysis
Substances
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Anti-Bacterial Agents
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Antimicrobial Cationic Peptides
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Carbapenems
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Arginine
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Proline
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Colistin