De Novo IgA Nephropathy in a Renal Allograft

Exp Clin Transplant. 2019 Aug;17(4):550-553. doi: 10.6002/ect.2016.0266. Epub 2017 Jun 28.

Abstract

Posttransplant glomerulonephritis is a complication of kidney transplant that can impair graft function and long-term graft survival. De novo immunoglobulin A disease in kidney allografts appears to be much less common than the recurrent disease, and in most cases it is diagnosed in protocol biopsies with no clinical evidence of disease or in association with other renal transplant pathologies such as chronic rejection. We present a case of de novo immunoglobulin A nephropathy presenting with overt proteinuria, microscopic hematuria, and progressive deterioration of renal function 30 months after renal transplant.

Publication types

  • Case Reports

MeSH terms

  • Disease Progression
  • Glomerulonephritis, IGA / diagnosis
  • Glomerulonephritis, IGA / immunology*
  • Glomerulonephritis, IGA / physiopathology
  • Glomerulonephritis, IGA / therapy
  • Hematuria / immunology
  • Hematuria / physiopathology
  • Humans
  • Immunoglobulin A / analysis*
  • Kidney / immunology*
  • Kidney / physiopathology
  • Kidney Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Proteinuria / immunology*
  • Proteinuria / physiopathology
  • Treatment Outcome

Substances

  • Immunoglobulin A