Abstract
Glucose-induced elevations in plasma immunoreactive insulin (IRI) were examined in anaesthetized rats pretreated with BW755c, sodium meclofenamate or vehicle. Neither drug influenced the glucose-induced hyperinsulinaemia or the glucose disappearance rate. The results do not support a physiological role for arachidonic acid metabolites in the regulation of glucose-induced insulin secretion.
MeSH terms
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4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
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Animals
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Anti-Inflammatory Agents / pharmacology*
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Glucose / pharmacology*
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Insulin / blood
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Insulin / metabolism*
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Insulin Secretion
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Male
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Meclofenamic Acid / pharmacology
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Pyrazoles / pharmacology*
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Rats
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Rats, Inbred Strains
Substances
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Anti-Inflammatory Agents
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Insulin
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Pyrazoles
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Meclofenamic Acid
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4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
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Glucose