Parvalbumin-expressing ependymal cells in rostral lateral ventricle wall adhesions contribute to aging-related ventricle stenosis in mice

J Comp Neurol. 2017 Oct 15;525(15):3266-3285. doi: 10.1002/cne.24276. Epub 2017 Jul 24.

Abstract

Aging-associated ependymal-cell pathologies can manifest as ventricular gliosis, ventricle enlargement, or ventricle stenosis. Ventricle stenosis and fusion of the lateral ventricle (LV) walls is associated with a massive decline of the proliferative capacities of the stem cell niche in the affected subventricular zone (SVZ) in aging mice. We examined the brains of adult C57BL/6 mice and found that ependymal cells located in the adhesions of the medial and lateral walls of the rostral LVs upregulated parvalbumin (PV) and displayed reactive phenotype, similarly to injury-reactive ependymal cells. However, PV+ ependymal cells in the LV-wall adhesions, unlike injury-reactive ones, did not express glial fibrillary acidic protein. S100B+/PV+ ependymal cells found in younger mice diminished in the LV-wall adhesions throughout aging. We found that periventricular PV-immunofluorescence showed positive correlation to the grade of LV stenosis in nonaged mice (<10-month-old), and that the extent of LV-wall adhesions and LV stenosis was significantly lower in mid-aged (>10-month-old) PV-knock out (PV-KO) mice. This suggests an involvement of PV+ ependymal cells in aging-associated ventricle stenosis. Additionally, we observed a time-shift in microglial activation in the LV-wall adhesions between age-grouped PV-KO and wild-type mice, suggesting a delay in microglial activation when PV is absent from ependymal cells. Our findings implicate that compromised ependymal cells of the adhering ependymal layers upregulate PV and display phenotype shift to "reactive" ependymal cells in aging-related ventricle stenosis; moreover, they also contribute to the progression of LV-wall fusion associated with a decline of the affected SVZ-stem cell niche in aged mice.

Keywords: RRID:AB_10000344; RRID:AB_1555288; RRID:AB_221568; RRID:AB_221569; RRID:AB_2315304; RRID:AB_2620025; RRID:AB_2665495; RRID:AB_839504; RRID:SCR_002285; RRID:SCR_002526; RRID:SCR_002798; aging; ependymal cell; lateral ventricle; parvalbumin; ventricle stenosis.

MeSH terms

  • Aging / metabolism*
  • Aging / pathology
  • Animals
  • Cell Adhesion / physiology
  • Constriction, Pathologic / metabolism
  • Constriction, Pathologic / pathology
  • Ependyma / metabolism*
  • Ependyma / pathology
  • Female
  • Fluorescent Antibody Technique
  • Forkhead Transcription Factors / genetics
  • Forkhead Transcription Factors / metabolism
  • Glial Fibrillary Acidic Protein / metabolism
  • Gliosis / metabolism
  • Gliosis / pathology
  • Green Fluorescent Proteins / genetics
  • Green Fluorescent Proteins / metabolism
  • Lateral Ventricles / metabolism*
  • Lateral Ventricles / pathology
  • Male
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Microglia / metabolism
  • Microglia / pathology
  • Microscopy, Confocal
  • Parvalbumins / genetics
  • Parvalbumins / metabolism*
  • S100 Calcium Binding Protein beta Subunit / metabolism

Substances

  • FOXJ1 protein, mouse
  • Forkhead Transcription Factors
  • Glial Fibrillary Acidic Protein
  • Parvalbumins
  • S100 Calcium Binding Protein beta Subunit
  • S100b protein, mouse
  • enhanced green fluorescent protein
  • Green Fluorescent Proteins