Drug-drug interaction related to the use of pipamperon and ondansetron in a child treated for leukemia

J Oncol Pharm Pract. 2018 Oct;24(7):537-539. doi: 10.1177/1078155217717325. Epub 2017 Jul 6.

Abstract

Pipamperon is a potent neuroleptic drug with many side effects, including prolongation of the QT interval. We report a case of a child treated for leukemia in which prolongation of the QT interval was observed. Physicians and pharmacists should be cautious for drug-drug interactions when pipamperon is prescribed, especially in combination with other QT-prolongating agents. Alternative strategies should be used whenever possible.

Keywords: Pipamperon; drug–drug interaction; leukemia; ondansetron.

Publication types

  • Case Reports

MeSH terms

  • Butyrophenones / administration & dosage
  • Butyrophenones / adverse effects*
  • Child
  • Drug Interactions
  • Electrocardiography / drug effects
  • Humans
  • Leukemia / drug therapy
  • Long QT Syndrome / chemically induced*
  • Male
  • Ondansetron / administration & dosage
  • Ondansetron / adverse effects*

Substances

  • Butyrophenones
  • Ondansetron
  • pipamperone