Sarcoidosis Presenting as Bilateral Vocal Fold Immobility

J Voice. 2018 May;32(3):359-362. doi: 10.1016/j.jvoice.2017.05.017. Epub 2017 Jul 3.

Abstract

Bilateral true vocal fold paralysis is rarely attributable to inflammatory diseases. Sarcoidosis is a rare but important etiology of bilateral true vocal fold paralysis by compressive lymphadenopathy, granulomatous infiltration, and neural involvement. We describe the first reported case of sarcoidosis presenting as bilateral vocal fold immobility caused by direct fixation by granulomatous infiltration severe enough to necessitate tracheostomy insertion. In addition, we discuss the presentation, the pathophysiology, and the treatment of this disease with a review of the literature of previously reported cases of sarcoidosis-related vocal fold immobility. Sarcoidosis should therefore be an important consideration for the otolaryngologist's differential diagnosis of true vocal fold immobility.

Keywords: Bilateral vocal fold immobility; Laryngeal sarcoidosis; Neurosarcoidosis; Respiratory sarcoidosis; Sarcoidosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Biopsy
  • Electromyography
  • Female
  • Humans
  • Laryngeal Diseases / complications*
  • Laryngeal Diseases / diagnosis
  • Laryngeal Diseases / physiopathology
  • Laryngeal Diseases / surgery
  • Laryngoscopy
  • Middle Aged
  • Sarcoidosis / complications*
  • Sarcoidosis / diagnosis
  • Sarcoidosis / physiopathology
  • Sarcoidosis / surgery
  • Tracheostomy
  • Treatment Outcome
  • Vocal Cord Paralysis / diagnosis
  • Vocal Cord Paralysis / etiology*
  • Vocal Cord Paralysis / physiopathology
  • Vocal Cords / physiopathology*
  • Voice Disorders / diagnosis
  • Voice Disorders / etiology*
  • Voice Disorders / physiopathology
  • Voice Quality