Regulation and functions of inflammasome-mediated cytokines in Helicobacter pylori infection

Le Son Tran; Michelle Chonwerawong; Richard L Ferrero

doi:10.1016/j.micinf.2017.06.005

Regulation and functions of inflammasome-mediated cytokines in Helicobacter pylori infection

Microbes Infect. 2017 Sep-Oct;19(9-10):449-458. doi: 10.1016/j.micinf.2017.06.005. Epub 2017 Jul 6.

Authors

Le Son Tran¹, Michelle Chonwerawong¹, Richard L Ferrero²

Affiliations

¹ Centre for Innate Immunity and Infectious Diseases, The Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria, Australia.
² Centre for Innate Immunity and Infectious Diseases, The Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria, Australia; Biomedicine Discovery Institute, Department of Microbiology, Monash University, Wellington Road, Clayton, Victoria, Australia. Electronic address: [email protected].

PMID: 28690082
DOI: 10.1016/j.micinf.2017.06.005

Abstract

Persistent stomach infection with Helicobacter pylori causes chronic mucosal inflammation (gastritis), which is widely recognized as an essential precursor to gastric cancer. The IL-1 interleukin family cytokines IL-1β and IL-18 have emerged as central mediators of mucosal inflammation. Here, we review the regulation and functions of these cytokines in H. pylori-induced inflammation and carcinogenesis.

Keywords: Gastric cancer; Helicobacter pylori; IL-18; IL-1β; Inflammasome; NOD-like receptors.

Publication types

Review

MeSH terms

Cytokines / genetics
Cytokines / metabolism*
Gene Expression Regulation / physiology
Helicobacter Infections / immunology
Helicobacter Infections / metabolism*
Helicobacter pylori
Humans
Inflammasomes / metabolism*
Stomach Neoplasms / etiology

Substances

Cytokines
Inflammasomes