Flow Synthesis of Diaryliodonium Triflates

J Org Chem. 2017 Nov 17;82(22):11735-11741. doi: 10.1021/acs.joc.7b01346. Epub 2017 Jul 20.

Abstract

A safe and scalable synthesis of diaryliodonium triflates was achieved using a practical continuous-flow design. A wide array of electron-rich to electron-deficient arenes could readily be transformed to their respective diaryliodonium salts on a gram scale, with residence times varying from 2 to 60 s (44 examples).

Publication types

  • Research Support, Non-U.S. Gov't