Abstract
Synthesis of the antimicrobial marine natural product halocyamine A has been achieved utilizing a combination of Sonogashira coupling, ruthenium complex/ytterbium triflate catalyzed hydroamidation and solid-phase peptide synthesis (SPPS) chemistry. The synthetic natural product exhibited only modest levels of antibacterial activities but significant antioxidant activity.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antioxidants / chemical synthesis
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Antioxidants / chemistry
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Antioxidants / pharmacology
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Biological Products / chemical synthesis
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Biological Products / chemistry
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Biological Products / pharmacology*
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Dose-Response Relationship, Drug
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Gram-Negative Bacteria / drug effects*
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Gram-Positive Bacteria / drug effects*
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Microbial Sensitivity Tests
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Molecular Structure
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Oligopeptides / chemical synthesis*
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Oligopeptides / chemistry
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Oligopeptides / pharmacology*
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Structure-Activity Relationship
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Urochordata / chemistry*
Substances
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Anti-Bacterial Agents
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Antioxidants
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Biological Products
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Oligopeptides
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halocyamine A