Development of low-cost photoacoustic imaging systems using very low-energy pulsed laser diodes

Ali Hariri; Afreen Fatima; Nafiseh Mohammadian; Sadreddin Mahmoodkalayeh; Mohammad Ali Ansari; Nicholas Bely; Mohammad R N Avanaki

doi:10.1117/1.JBO.22.7.075001

Development of low-cost photoacoustic imaging systems using very low-energy pulsed laser diodes

J Biomed Opt. 2017 Jul 1;22(7):75001. doi: 10.1117/1.JBO.22.7.075001.

Authors

Ali Hariri¹, Afreen Fatima², Nafiseh Mohammadian², Sadreddin Mahmoodkalayeh³, Mohammad Ali Ansari³, Nicholas Bely², Mohammad R N Avanaki⁴

Affiliations

¹ Wayne State University, Bioengineering Department, Detroit, Michigan, United StatesbUniversity of California, Department of NanoEngineering, San Diego, California, United States.
² Wayne State University, Bioengineering Department, Detroit, Michigan, United States.
³ Shahid Beheshti University, Laser and Plasma Research Institute, Tehran, Iran.
⁴ Wayne State University, Bioengineering Department, Detroit, Michigan, United StatesdWayne State University, School of Medicine, Department Neurology, Detroit, Michigan, United StateseBarbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States.

PMID: 28697234
DOI: 10.1117/1.JBO.22.7.075001

Abstract

With the growing application of photoacoustic imaging (PAI) in medical fields, there is a need to make them more compact, portable, and affordable. Therefore, we designed very low-cost PAI systems by replacing the expensive and sophisticated laser with a very low-energy laser diode. We implemented photoacoustic (PA) microscopy, both reflection and transmission modes, as well as PA computed tomography systems. The images obtained from tissue-mimicking phantoms and biological samples determine the feasibility of using a very low-energy laser diode in these configurations.

MeSH terms

Lasers, Semiconductor*
Microscopy
Phantoms, Imaging
Photoacoustic Techniques / economics
Photoacoustic Techniques / instrumentation*