Three relapses after a haploidentical transplantation in a pediatric patient: Cure with no further transplantation

Vedat Uygun; Hayriye Daloglu; Seda Öztürkmen; Gulsun Karasu; Akif Yesilipek

doi:10.1111/petr.13005

Three relapses after a haploidentical transplantation in a pediatric patient: Cure with no further transplantation

Pediatr Transplant. 2017 Sep;21(6). doi: 10.1111/petr.13005. Epub 2017 Jul 13.

Authors

Vedat Uygun¹, Hayriye Daloglu², Seda Öztürkmen², Gulsun Karasu¹, Akif Yesilipek¹

Affiliations

¹ Bahçeşehir University, Faculty of Medicine, MedicalPark Antalya Hospital, Pediatric BMT Unit, Antalya, Turkey.
² MedicalPark Antalya Hospital, Pediatric BMT Unit, Antalya, Turkey.

PMID: 28703407
DOI: 10.1111/petr.13005

Abstract

Isolated extramedullary relapse (EMR) after hematopoietic stem cell transplantation (HSCT) is a highly fatal condition that creates uncertainty regarding treatment options. Although certain approaches such as repeat HSCT and donor lymphocyte infusion are recommended, we report a patient with acute lymphoblastic leukemia who had three isolated EMRs after HSCT at different locations and at different times that were responsive to local and systemic therapies, without the need for a second transplantation.

Keywords: extramedullary relapse; hematopoetic stem cell transplantation; leukemia.

Publication types

Case Reports

MeSH terms

Child, Preschool
Hematopoietic Stem Cell Transplantation / methods*
Humans
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
Recurrence
Transplantation, Haploidentical*