A Case of Decreased Susceptibility to Ceftriaxone in Neisseria gonorrhoeae in the Absence of a Mosaic Penicillin-Binding Protein 2 (penA) Allele

Sex Transm Dis. 2017 Aug;44(8):492-494. doi: 10.1097/OLQ.0000000000000645.

Abstract

We report a case of Neisseria gonorrhoeae with a non-mosaic penA allele that exhibited decreased susceptibility to extended-spectrum cephalosporins, including a ceftriaxone minimum inhibitory concentration of 0.5 μg/mL. An analysis of resistance determinants suggested that the observed phenotype might have resulted from the combined effects of mutations in multiple genes.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alleles
  • Anti-Bacterial Agents / pharmacology*
  • Carrier Proteins / genetics*
  • Ceftriaxone / pharmacology*
  • Drug Resistance, Bacterial / genetics*
  • Gonorrhea / microbiology*
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Mutation
  • Neisseria gonorrhoeae / drug effects
  • Neisseria gonorrhoeae / genetics*
  • Phenotype
  • Serine-Type D-Ala-D-Ala Carboxypeptidase
  • Urethra / microbiology
  • Urethritis

Substances

  • Anti-Bacterial Agents
  • Carrier Proteins
  • Ceftriaxone
  • Serine-Type D-Ala-D-Ala Carboxypeptidase
  • penicillin-binding protein 2, Neisseria gonorrhoeae