Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing

Jamie A Murkey; Kara W Chew; Margrit Carlson; Chelsea L Shannon; Deepika Sirohi; Hannah A Sample; Michael R Wilson; Paul Vespa; Romney M Humphries; Steve Miller; Jeffrey D Klausner; Charles Y Chiu

doi:10.1093/ofid/ofx121

Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing

Open Forum Infect Dis. 2017 Jun 13;4(3):ofx121. doi: 10.1093/ofid/ofx121. eCollection 2017 Summer.

Authors

Affiliations

¹ Department of Medicine.
² Department of Laboratory Medicine.
³ Department of Biochemistry and Biophysics.
⁴ Weill Institute for Neurosciences, Department of Neurology.
⁵ Department of Neurology, and.
⁶ Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles; and.
⁷ UCSF-Abbott Viral Diagnostics and Discovery Center and Department of Medicine, and.
⁸ Department of Medicine, Division of Infectious Diseases, University of California, San Francisco.

Abstract

Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation.

Keywords: encephalitis; hepatitis E virus; lung transplant; meningitis; metagenomic next-generation sequencing (mNGS)..

Abstract

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