Population specific analysis of Yakut exomes

A S Zlobin; S Sh Sharapov; V P Guryev; M R Bevova; Y A Tsepilov; T M Sivtseva; U A Boyarskih; E A Sokolova; Y S Aulchenko; M L Filipenko; V L Osakovsky

doi:10.1134/S1607672917030188

Population specific analysis of Yakut exomes

Dokl Biochem Biophys. 2017 May;474(1):213-216. doi: 10.1134/S1607672917030188. Epub 2017 Jul 20.

Authors

A S Zlobin^{1

2}, S Sh Sharapov^{3

4}, V P Guryev⁵, M R Bevova⁵, Y A Tsepilov^{3

4}, T M Sivtseva⁶, U A Boyarskih^{3

7}, E A Sokolova^{3

7}, Y S Aulchenko^{3

4}, M L Filipenko^{3

7}, V L Osakovsky⁶

Affiliations

¹ Novosibirsk State University, Novosibirsk, 630090, Russia. [email protected].
² Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia. [email protected].
³ Novosibirsk State University, Novosibirsk, 630090, Russia.
⁴ Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia.
⁵ European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen, The Netherlands.
⁶ Research Institute of Health, Ammosov North-Eastern Federal University, Yakutsk, Russia.
⁷ Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia.

PMID: 28726087
DOI: 10.1134/S1607672917030188

Abstract

We studied the genetic diversity of the Yakut population using exome sequencing. We performed comparative analysis of the Yakut population and the populations that are included in the "1000 Genomes" project and we identified the alleles specific to the Yakut population. We showed, that the Yakuts population is a separate cluster between Europeans and East Asians.

MeSH terms

Ethnicity / genetics*
Exome / genetics*
Genetic Variation*
Heterozygote
Homozygote
Humans
Polymorphism, Single Nucleotide