Abstract
A versatile drug delivery system with dual specific capacity of controllable release and monitoring of the intracellular release process, which extremely maximize therapeutic efficacy on diseased cells while minimizing drug toxicity to healthy cells, was reported for the first time.
MeSH terms
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacokinetics*
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Antineoplastic Agents / pharmacology
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Biomarkers, Tumor / chemistry
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Biomarkers, Tumor / metabolism*
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Cell Survival / drug effects
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DNA, Neoplasm / chemistry
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DNA, Neoplasm / metabolism*
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Drug Carriers / chemistry
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Drug Carriers / metabolism
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Drug Delivery Systems*
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Humans
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Nanoparticles / chemistry
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Nanoparticles / metabolism*
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Neoplasms / metabolism
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Neoplasms / pathology
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Particle Size
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Porosity
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Silicon Dioxide / chemistry
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Silicon Dioxide / metabolism*
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Surface Properties
Substances
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Antineoplastic Agents
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Biomarkers, Tumor
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DNA, Neoplasm
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Drug Carriers
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Silicon Dioxide