Nuclear Pore Complexes: A Scaffold Regulating Developmental Transcription?

Atsushi Satomura; Jason H Brickner

doi:10.1016/j.tcb.2017.07.002

Nuclear Pore Complexes: A Scaffold Regulating Developmental Transcription?

Trends Cell Biol. 2017 Sep;27(9):621-622. doi: 10.1016/j.tcb.2017.07.002. Epub 2017 Jul 19.

Authors

Atsushi Satomura¹, Jason H Brickner²

Affiliations

¹ Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
² Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA. Electronic address: [email protected].

Abstract

Nuclear pore complexes (NPCs) have a conserved, but poorly understood, role in transcriptional regulation. Recently, in Developmental Cell, Raices et al. argued that tissue-specific nuclear pore proteins (Nups) act as scaffolds that recruit the transcription factor Mef2C to the NPC, promoting transcription of NPC-associated genes during muscle development.

Keywords: differentiation; nuclear architecture; nuclear pore complex; transcription.

MeSH terms

Animals
Gene Expression Regulation, Developmental / physiology*
Humans
Muscle Development / physiology*
Nuclear Pore / metabolism*
Nuclear Pore Complex Proteins / metabolism*
Transcription, Genetic / physiology*

Substances

Nuclear Pore Complex Proteins

Abstract

MeSH terms

Substances

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