Draft genome sequence of a multidrug-resistant Aeromonas hydrophila ST508 strain carrying rmtD and blaCTX-M-131 isolated from a bloodstream infection

Quézia Moura; Miriam R Fernandes; Louise Cerdeira; Ana Carolina M Santos; Tiago A de Souza; Susan Ienne; Antonio Carlos C Pignatari; Ana C Gales; Rosa M Silva; Nilton Lincopan

doi:10.1016/j.jgar.2017.07.007

Draft genome sequence of a multidrug-resistant Aeromonas hydrophila ST508 strain carrying rmtD and bla_CTX-M-131 isolated from a bloodstream infection

J Glob Antimicrob Resist. 2017 Sep:10:289-290. doi: 10.1016/j.jgar.2017.07.007. Epub 2017 Jul 21.

Authors

Affiliations

¹ Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: [email protected].
² Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, Brazil.
³ Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
⁴ Genome Investigation and Analysis Laboratory (GENIAL), Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
⁵ Laboratório Alerta, Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
⁶ Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, Brazil. Electronic address: [email protected].

PMID: 28739226
DOI: 10.1016/j.jgar.2017.07.007

Abstract

Here we report the draft genome sequence of a multidrug-resistant (MDR) Aeromonas hydrophila strain belonging to sequence type 508 (ST508) isolated from a human bloodstream infection. Assembly and annotation of this draft genome resulted in 5028498bp and revealed the presence of 16S rRNA methylase rmtD and bla_CTX-M-131 genes encoding high-level resistance to aminoglycosides and cephalosporins, respectively, as well as multiple virulence genes. This draft genome can provide significant information for understanding mechanisms on the establishment and treatment of infections caused by this pathogen.

Keywords: 16S rRNA methylase; Aeromonas hydrophila; Brazil; ESBL; Extended-spectrum β-lactamase; Whole-genome sequencing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aeromonas hydrophila / drug effects
Aeromonas hydrophila / genetics*
Bacteremia / microbiology*
Bacterial Proteins / genetics
Drug Resistance, Multiple, Bacterial*
Genome, Bacterial
Gram-Negative Bacterial Infections / microbiology*
High-Throughput Nucleotide Sequencing
Humans
Microbial Sensitivity Tests
Molecular Sequence Annotation
Whole Genome Sequencing / methods*
tRNA Methyltransferases

Substances

Bacterial Proteins
tRNA Methyltransferases