CCL3 is a key mediator for the leukemogenic effect of Ptpn11-activating mutations in the stem-cell microenvironment

Blood. 2017 Sep 21;130(12):1471-1474. doi: 10.1182/blood-2017-06-791103. Epub 2017 Jul 27.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Bone Marrow / pathology
  • Cell Transformation, Neoplastic / genetics
  • Chemokine CCL3 / antagonists & inhibitors
  • Chemokine CCL3 / deficiency
  • Chemokine CCL3 / genetics
  • Chemokine CCL3 / physiology*
  • Germ-Line Mutation
  • Humans
  • Leukemia, Experimental / genetics*
  • Leukemia, Experimental / pathology
  • Liver / pathology
  • Lung / pathology
  • Mesenchymal Stem Cells / metabolism
  • Mesenchymal Stem Cells / pathology
  • Mice
  • Mice, Knockout
  • Mutation, Missense*
  • Neoplastic Stem Cells / metabolism
  • Neoplastic Stem Cells / pathology
  • Noonan Syndrome / genetics
  • Point Mutation*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics*
  • Spleen / pathology
  • Tumor Microenvironment

Substances

  • Ccl3 protein, mouse
  • Chemokine CCL3
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Ptpn11 protein, mouse