Effect of tunable redox behavior of bis chelate substituted 1,10-phenantroline Cu(II) complexes on its reaction with superoxide anion in DMSO. Toward a simple criterion to identify a SOD-like mechanism

J Inorg Biochem. 2017 Oct:175:118-128. doi: 10.1016/j.jinorgbio.2017.07.013. Epub 2017 Jul 18.

Abstract

In this work we report a series of Cu(II) complexes [Cu(N-N)2(X)]+, (N-N=substituted 1,10-phenanthroline derivatives and X=Cl- or NO3-), with tunable E1/2 for electrochemical reduction [CuII(N-N)2(X)]++1e-⇌[CuI(N-N)2]+X-. The disproportion of O2•- was explored in presence of the electro-generated species [CuI(N-N)2]+ using cyclic voltammetry in a non-aqueous media, arising a new simple method to propose a SOD-like mechanism, which can be used as a quick guide test for a compound, before being proven in biological assays. It was found that complexes with high negative half wave potential values (E1/2) for Cu(II)/Cu(I) couple shown a current increment for oxygen reduction, related to the capability of the disproportion of this reactive oxygen species.

Keywords: Biomimetic metal complexes; Copper (II)-1,10-phenantroline complexes; Electrochemistry; SOD-like mechanism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chelating Agents* / chemical synthesis
  • Chelating Agents* / chemistry
  • Copper / chemistry*
  • Dimethyl Sulfoxide / chemistry*
  • Phenanthrolines / chemistry*
  • Superoxide Dismutase*
  • Superoxides / chemistry*

Substances

  • Chelating Agents
  • Phenanthrolines
  • Superoxides
  • Copper
  • Superoxide Dismutase
  • 1,10-phenanthroline
  • Dimethyl Sulfoxide