TiF4 gel effects on tubular occlusion of eroded/abraded human dentin

Microsc Res Tech. 2017 Nov;80(11):1182-1188. doi: 10.1002/jemt.22915. Epub 2017 Jul 31.

Abstract

This in situ study evaluated the tubular occlusion caused by 4% TiF4 gel on the surface of eroded/abraded dentin. Sixty human dentin samples were eroded in vitro and assigned into six groups (n = 10) according to the in situ surface treatment and number of cycling days: 4% TiF4 gel applied once (TiF4 1), twice (TiF4 2), or three times (TiF4 3) followed by 2, 4, and 6 days of erosive/abrasive in situ cycling, respectively. Control groups (no treatment) were subjected to 2 (C1), 4 (C2), and 6 (C3) days of erosive/abrasive in situ cycling only. A seventh group (n = 10) was comprised by in vitro uneroded samples (UN), subjected to 6 days of in situ erosive/abrasive cycling. Each cycling day consisted on six erosive (0.5% citric acid, pH 2.6) and one abrasive events. Environmental scanning electron microscopy micrographs were taken. For all groups, blinded examiners assessed dentin tubules occlusion using visual scores (0-unoccluded, 1-partially occluded by granular deposits, 2-partially occluded by reduction in tubular lumen into diamond shape, 3-completely occluded) on images captured prior and after the in situ phase. Scheirer-Ray-Hare test demonstrated that treatments significantly affected tubule occlusion (p < .001). Dunn's test showed that tubule occlusion in TiF4 3 was significantly higher than in C1. Tubule occlusion in remaining groups did not differ from that observed in groups TiF4 3 and C1. Tubule occlusion was significantly higher after in situ phase. It may be suggested that TiF4 , when applied three times, was able to positively change tubule occlusion of dentin samples.

Keywords: dental erosion; environmental SEM; surface morphology; titanium tetrafluoride.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Cariostatic Agents / pharmacology*
  • Dentin / drug effects*
  • Dentin / pathology
  • Dentin / ultrastructure
  • Female
  • Fluorides / pharmacology*
  • Fluorides, Topical
  • Gels
  • Humans
  • Microscopy, Electron, Scanning
  • Single-Blind Method
  • Titanium / pharmacology*
  • Tooth Abrasion / drug therapy
  • Tooth Erosion / drug therapy
  • Young Adult

Substances

  • Cariostatic Agents
  • Fluorides, Topical
  • Gels
  • Titanium
  • Fluorides
  • titanium tetrafluoride